Name | 2-Fluoro-5-Trifluoromethylpyridine |
Synonyms | uoro-6-(trifL 2-Fluoro-5-(Trichloromethyl)Py 2-Fluoro-5-trifluoromethylpyridine 2-Fluoro-5-Trifluoromethylpyridine 2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 2-fluoro-5-(trifluoromethyl)pyridine Pyridine, 2-fluoro-5-(trifluoroMethyl)- |
CAS | 69045-82-5 |
EINECS | 400-290-2 |
InChI | InChI=1/C6H3F4N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H |
Molecular Formula | C6H3F4N |
Molar Mass | 165.09 |
Density | 1.368 g/mL at 25 °C |
Boling Point | 118-122℃ |
Flash Point | 35°(95°F) |
Vapor Presure | 9.61mmHg at 25°C |
pKa | -2.86±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.4020 |
MDL | MFCD07437945 |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R43 - May cause sensitization by skin contact R10 - Flammable |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S37 - Wear suitable gloves. S24 - Avoid contact with skin. S36 - Wear suitable protective clothing. S27 - Take off immediately all contaminated clothing. |
UN IDs | 1993 |
WGK Germany | 3 |
HS Code | 29333990 |
Hazard Note | Irritant |
Hazard Class | 3 |
Packing Group | Ⅲ |
application | 2-fluoro-5-trifluoromethylpyridine is an important chemical intermediate raw material. by introducing fluorine atoms into pyridine ring and pyridine side chain, it has strong lipophilicity and can play an important role in pesticides and medicine. its application value and market prospect are very considerable. |
Preparation method | The synthesis steps of 2-fluoro-5-trifluoromethylpyridine:(1) Using 3-methylpyridine as raw material, one-step chlorination Synthesis of 2-chloro-5-trichloromethylpyridine crude product;(2) Using purified 2-chloro-5-trichloromethylpyridine as raw material, using anhydrous HF as a fluorination reagent, one-step fluorination synthesis of 2-fluoro-5-trifluoromethylpyridine crude;(3) the oil layer after alkali washing and water washing, after decompression distillation to obtain high-purity 2-fluoro-5-trifluoromethylpyridine. |